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ANDREOTTI V.-CIRIBILLI Y.-MONTI P.-BISIO A.-LION M.-JORDAN J.-
FRONZA G.-MENICHINI P.-RESNICK M.-INGA A.
p53 transactivation and the impact of mutations, cofactors and
small molecules using a simplified yeast based screening system.
PLoS One 6(6):e20643;1/e20643;15, 2011
PubMed Abstract
FORESTA M.-FROSINA G.-SACCA S.-CARTIGLIA C.-LONGOBARDI M.-IZZOTTI A.
Increased resistance to oxidative DNA damage of trabecular
meshwork cells by E. coli FPG gene transfection.
Free Radic. Res. 45(7):751/758, 2011
PubMed Abstract
FROSINA G.
Stem cell mediated delivery of therapies in the treatment of
glioma.
Mini Rev. Med. Chem. 11:591/598, 2011
PubMed Abstract
MONTI P.-BROXSON C.-INGA A.-WANG R.-MENICHINI P.-TORNALETTI S.-
GOLD B.-FRONZA G.
3/Methyl/3/deazaadenine, a stable isostere of N3/methyl/adenine,
is efficiently bypassed by replication in vivo and by
transcription in vitro.
DNA Repair (Amst) 10:861/868, 2011
PubMed Abstract
MONTI P.-PERFUMO C.-BISIO A.-CIRIBILLI Y.-MENICHINI P.-RUSSO D.-
UMBACH D.-RESNICK M.-INGA A.-FRONZA G.
Dominant negative features of mutant TP53 in germline carriers
have limited impact on cancer outcomes.
Mol. Cancer Res. 9(3):271/279, 2011
PubMed Abstract
ROPOLO M.-CAPPELLI E.-FORESTA M.-POGGI A.-PROIETTI DE SANTIS L.-
FROSINA G.
Defective resolution of pH2AX foci and enhanced DNA breakage in
ionizing radiation treated cockayne syndrome B cells.
IUBMB Life 63(4):272/276, 2011
PubMed Abstract
BISIO A.-NASTI S.-JORDAN J.-GARGIULO S.-PASTORINO L.-PROVENZANI A.-
QUATTRONE A.-QUEIROLO P.-BIANCHI SCARRA' G.-GHIORZO P.-INGA A.
Functional analysis of CDKN2A/p16INK4a 5'/UTR variants
predisposing to melanoma.
Hum. Mol. Genet. 19(8):1479/1491, 2010
PubMed Abstract
CASORELLI I.-PANNELLINI T.-DE LUCA G.-DEGAN P.-CHIERA F.-IAVARONE
I.-GIULIANI A.-BUTERA A.-BOIRIVANT M.-MUSIANI P.-BIGNAMI M.
The Mutyh base excision repair gene influences the inflammatory
response in a mouse model of ulcerative colitis.
PLoS One 5(8):e12070;1/e12070;11, 2010
PubMed Abstract
CIRIBILLI Y.-ANDREOTTI V.-MENENDEZ D.-LANGEN J.-SCHOENFELDER G.-
RESNICK M.-INGA A.
The coordinated p53 and estrogen receptor cis regulation at an
FLT1 promoter SNP is specific to genotoxic stress and estrogenic
compound.
PLoS One 5(4):e10236;1/e10236;15, 2010
PubMed Abstract
CUCCAROLO P.-BARBIERI F.-SANCANDI M.-VIAGGI S.-DEGAN P.
Differential behaviour of normal, transformed and Fanconi's anemia
lymphoblastoid cells to modeled microgravity.
J. Biomed. Sci. 17:63;1/63;10, 2010
PubMed Abstract
FROSINA G.
Frontiers in targeting glioma stem cells.
Eur. J. Cancer 47:496/507, 2011 - Epub Dec 22, 2010
PubMed Abstract
FROSINA G.
The bright and the dark sides of DNA repair in stem cells.
J. Biomed. Biotechnol. 2010:845396;1/845396;14, 2010
PubMed Abstract
GOITRE L.-BALZAC F.-DEGANI S.-DEGAN P.-MARCHI S.-PINTON P.-RETTA S.
KRIT1 regulates the homeostasis of intracellular reactive oxygen species.
PLoS One 5(7):e11786;1/e11786;22, 2010
PubMed Abstract
PARODI St.-PERFUMO C.-GARAVENTA A.-INGA A.-MAZZOCCO K.-DEFFERRARI
R.-TONINI G.P.-FRONZA G.-HAUPT R.
MDM2 SNP309 genotype is associated with ferritin and LDH serum
levels in children with stage 4 neuroblastoma.
Pediatr. Blood Cancer 55:267/272, 2010
PubMed Abstract
RUSSO D.-FRONZA G.-OTTAGGIO L.-MONTI P.-PERFUMO C.-INGA A.-IYER P.-
GOLD B.-MENICHINI P.
XRCC1 deficiency influences the cytotoxicity and the genomic
instability induced by Me/lex, a specific inducer of
N3/methyladenine.
DNA Repair (Amst) 9:728/736, 2010
PubMed Abstract
RUSSO D.-OTTAGGIO L.-PENNA I.-FOGGETTI G.-FRONZA G.-INGA A.-
MENICHINI P.
PRIMA/1 cytotoxicity correlates with nucleolar localization and
degradation of mutant p53 in breast cancer cells.
Biochem. Biophys. Res. Commun. 402:345/350, 2010
PubMed Abstract
SETTLES S.-WANG R.-FRONZA G.-GOLD B.
Effect of N3/methyladenine and an isosteric stable analogue on DNA
polymerization.
J. Nucleic Acids 2010:426505;1/426505;14, 2010
PubMed Abstract
CASARTELLI G.-DORCARATTO A.-RAVETTI J.-SOLA S.-VITALI A.-MERLO
D.F.-FROSINA G.
Survival of high grade glioma patients depends on their age at
diagnosis.
Cancer Biol. Ther. 8:1719/1721, 2009
PubMed Abstract
FORESTA M.-ROPOLO M.-DEGAN P.-PETTINATI I.-KOW Y.-DAMONTE G.-POGGI
A.-FROSINA G.
Defective repair of 5/hydroxy/2'/deoxycytidine in Cockayne
syndrome cells and its complementation by Escherichia coli
formamidopyrimidine DNA glycosylase and endonuclease III.
Free Radic. Biol. Med. 48:681/690, 2010 - Epub Dec 21, 2009
PubMed Abstract
FROSINA G.
DNA repair in normal and cancer stem cells, with special reference
to the central nervous system.
Curr. Med. Chem. 16:854/866, 2009
PubMed Abstract
FROSINA G.
DNA repair and resistance of gliomas to chemotherapy and
radiotherapy.
Mol. Cancer Res. 7:989/999, 2009
PubMed Abstract
MENENDEZ D.-INGA A.-RESNICK M.
The expanding universe of p53 targets.
Nat. Rev. Cancer 9:724/737, 2009
PubMed Abstract
MOLATORE S.-RUSSO M.-D'AGOSTINO V.-BARONE F.-MATSUMOTO Y.-
ALBERTINI A.-MINOPRIO A.-DEGAN P.-MAZZEI F.-BIGNAMI M.-RANZANI G.
MUTYH mutations associated with familial adenomatous polyposis:
functional characterization by a mammalian cell based assay.
Hum. Mutat. 31:159/166, 2010 - Epub Dec 1, 2009
PubMed Abstract
MONTI P.-TRAVERSO I.-CASOLARI L.-MENICHINI P.-INGA A.-OTTAGGIO L.-
RUSSO D.-IYER P.-GOLD B.-FRONZA G.
Mutagenicity of N3/methyadenine: a multi translesion polymerase
affair.
Mutat. Res. Fund. Mol. M. 683:50/56, 2010 - Epub Oct 26, 2009
PubMed Abstract
PERFUMO C.-PARODI St.-MAZZOCCO K.-DEFFERRARI R.-INGA A.-BIANCHI
SCARRA' G.-GHIORZO P.-HAUPT R.-TONINI G.P.-FRONZA G.
MDM2 SNP309 genotype influences survival of metastatic but not of
localized neuroblastoma.
Pediatr. Blood Cancer 53:576/583, 2009
PubMed Abstract
REAMON BUETTNER S.-CIRIBILLI Y.-TRAVERSO I.-KUHLS B.-INGA A.-
BORLAK J.
A functional genetic study identifies HAND1 mutations in septation
defects of the human heart.
Hum. Mol. Genet. 18:3567/3578, 2009
PubMed Abstract
ROPOLO M.-DAGA A.-GRIFFERO F.-FORESTA M.-CASARTELLI G.-ZUNINO A.-
POGGI A.-CAPPELLI E.-ZONA G.-SPAZIANTE R.-CORTE G.-FROSINA G.
Comparative analysis of DNA repair in stem and nonstem glioma cell
cultures.
Mol. Cancer Res. 7:383/392, 2009
PubMed Abstract
RUSSO D.-FRONZA G.-OTTAGGIO L.-MONTI P.-INGA A.-IYER P.-GOLD B.-
MENICHINI P.
High frequency of genomic deletions induced by Me/lex, a sequence
selective N3/adenine methylating agent, at the Hprt locus in
Chinese hamster ovary cells.
Mutat. Res. Fund. Mol. M. 671:58/66, 2009
PubMed Abstract
RUSSO M.-DE LUCA G.-CASORELLI I.-DEGAN P.-MOLATORE S.-BARONE F.-
MAZZEI F.-PANNELLINI T.-MUSIANI P.-BIGNAMI M.
Role of MUTYH and MSH2 in the control of oxidative DNA damage,
genetic instability, and tumorigenesis.
Cancer Res. 69:4372/4379, 2009
PubMed Abstract
CAPRA V.-CONSALES A.-NOZZA P.-MONTI P.-INGA A.-FRONZA G.
Identification of a novel TP53 germline mutation in a large
italian Li Fraumeni syndrome family. Letter.
Pediatr. Blood Cancer 52:303/308, 2009 - Epub Oct 20, 2008
PubMed Abstract
DE LUCA G.-RUSSO M.-DEGAN P.-TIVERON C.-ZIJNO A.-MECCIA E.-VENTURA
I.-MATTEI E.-NAKABEPPU Y.-CRESCENZI M.-PEPPONI R.-PEZZOLA A.-
POPOLI P.-BIGNAMI M.
A role for oxidized DNA precursors in Huntington's disease like
striatal neurodegeneration.
PLoS Genet. 4:e1000226;1/e1000266;14, 2008
PubMed Abstract
FROSINA G.
Oxidatively damaged DNA repair defect in Cockayne syndrome and its
complementation by heterologous repair proteins.
Curr. Med. Chem. 15:940/953, 2008
PubMed Abstract
IZZOTTI A.-D'AGOSTINI F.-BALANSKY R.-DEGAN P.-PENNISI T.-STEELE V.-
DE FLORA S.
Exposure of mice to cigarette smoke and/or light causes DNA
alterations in heart and aorta.
Mutat. Res. Fund. Mol. M. 644:38/42, 2008
PubMed Abstract
JEGGA A.-INGA A.-MENENDEZ D.-ARONOW B.-RESNICK M.
Functional evolution of the p53 regulatory network through its
target response elements.
Proc. Natl. Acad. Sci. USA 105:944/949, 2008
PubMed Abstract
JORDAN J.-MENENDEZ D.-INGA A.-NOURREDINE M.-BELL D.-RESNICK M.
Noncanonical DNA motifs as transactivation targets by wild type
and mutant p53.
PLoS Genet. 7:e1000104;1/e1000104;18, 2008
PubMed Abstract
MAGRINI R.-RUSSO D.-OTTAGGIO L.-FRONZA G.-INGA A.-MENICHINI P.
PRIMA/1 synergizes with adriamycin to induce cell death in non
small cell lung cancer cells.
J. Cell. Biochem. 104:2363/2373, 2008
PubMed Abstract
MONTI P.-CIRIBILLI Y.-RUSSO D.-BISIO A.-PERFUMO C.-ANDREOTTI V.-MENICHINI P.-INGA A.-HUANG X.-GOLD B.-FRONZA G.
Rev1 and Polzeta influence toxicity and mutagenicity of Me/lex, a
sequence selective N3/adenine methylating agent.
DNA Repair (Amst) 7:431/438, 2008
PubMed Abstract
PERFUMO C.-PARODI St.-MAZZOCCO K.-DEFFERRARI R.-INGA A.-HAUPT R.-
FRONZA G.-TONINI G.P.
Impact of MDM2 SNP309 genotype on progression and survival of
stage 4 neuroblastoma.
Eur. J. Cancer 44:2634/2639, 2008
PubMed Abstract
REAMON BUETTNER S.-CIRIBILLI Y.-INGA A.-BORLAK J.
A loss of function mutation in the binding domain of HAND1
predicts hypoplasia of the human hearts.
Hum. Mol. Genet. 17:1397/1405, 2008
PubMed Abstract
BIANCHI M.-BELLINI A.-CERVELLI M.-DEGAN P.-MARCOCCI L.-MARTINI F.-SCATTEIA M.-MARIOTTINI P.-AMENDOLA R.
Chronic sub lethal oxidative stress by spermine oxidase overactivity induces continuous DNA repair and hypersensitivity to
radiation exposure.
Biochim. Biophys. Acta Mol. Cell Res. 1773:774/783, 2007
PubMed Abstract
BOFFA L.-MENICHINI P.-BOLOGNESI C.-CUTRONA G.-RONCELLA S.-DAMONTE G.-MILLO E.-MARIANI M.-MATIS S.-RUSSO D.-CILIUTTI P.-FERRARINI M.
Lack of mutagenicity and clastogenicity of PNAEmu/NLS targeted to a regulatory sequence of the translocated c/myc oncogene in
Burkitt's lymphoma.
Mutat. Res. Gen. Tox. En. 628:129/137, 2007
PubMed Abstract
CARDELLINO U.-CIRIBILLI Y.-ANDREOTTI V.-MODESTO P.-MENICHINI P.-FRONZA G.-PELLEGRINO
C.-INGA A.
Transcriptional properties of feline p53 and its tumour associated mutants:
a yeast based approach.
Mutagenesis 22:417/423, 2007
PubMed Abstract
CHIERA F.-MECCIA E.-DEGAN P.-AQUILINA G.-PIETRAFORTE D.-MINETTI M.-LAMBETH D.-BIGNAMI
M.
Overexpression of human NOX1 complex induces genome instability in
mammalian cells.
Free Radic. Biol. Med. 44:332/342, 2008 - Epub Oct 6, 2007
PubMed Abstract
DEGAN P.-D'ISCHIA M.-PALLARDO' F.-ZATTERALE A.-BRUSCO A.-CALZONE R.-CAVALIERI S.-KAVAKLI K.-LLORET A.-MANINI P.-PISANTI M.-
VUTTARIELLO E.-PAGANO G.
Glutathione levels in blood from ataxia telangiectasia patients suggest in vivo adaptive mechanisms to oxidative stress.
Clin. Biochem. 40:666/670, 2007
PubMed Abstract
D'ERRICO M.-PARLANTI E.-TESON M.-DEGAN P.-LEMMA T.-CALCAGNILE A.-IAVARONE I.-JARUGA P.-ROPOLO M.-PEDRINI A.-ORIOLI D.-FROSINA G.-
ZAMBRUNO G.-DIZDAROGLU M.-STEFANINI M.-DOGLIOTTI E.
The role of CSA in the response to oxidative DNA damage in human cells.
Oncogene 26:4336/4343, 2007
PubMed Abstract
FROSINA G.
The current evidence for defective repair of oxidatively damaged DNA in Cockayne sindrome.
Free Radic. Biol. Med. 43:165/177, 2007
PubMed Abstract
FROSINA G.
Tumor suppression by DNA base excision repair.
Mini Rev. Med. Chem. 7:727/743, 2007
PubMed Abstract
FROSINA G.
Preface.
Mol. Aspects Med. 28:255/257, 2007
FROSINA G.
Gene prophylaxis by a DNA repair function.
Mol. Aspects Med. 28:323/344, 2007
PubMed Abstract
LLORET A.-CALZONE R.-DUNSTER C.-MANINI P.-D'ISCHIA M.-DEGAN P.-KELLY
F.-PALLARDO' F.-ZATTERALE A.-PAGANO G.
Different patterns of in vivo pro oxidant states in a set of cancer or
aging related genetic diseases.
Free Radic. Biol. Med. 44:495/503 - Epub Oct 30, 2007
PubMed Abstract
MENENDEZ D.-INGA A.-JORDAN J.-RESNICK M.
Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson.
Oncogene 26:2191/2201, 2007
PubMed Abstract
MENENDEZ D.-INGA A.-SNIPE J.-KRYSIAK O.-SCHONFELDER G.-RESNICK M.
A single nucleotide polymorphism in a half binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1.
Mol. Cell. Biol. 27:2590/2600, 2007
PubMed Abstract
MONTI P.-CIRIBILLI Y.-JORDAN J.-MENICHINI P.-UMBACH D.-RESNICK M.-LUZZATTO L.-INGA A.-FRONZA G.
Transcriptional functionality of Germ line p53 mutants influences cancer phenotype.
Clin. Cancer Res. 13:3789/3795, 2007
PubMed Abstract
MONTICONE M.-TONACHINI L.-TAVELLA S.-DEGAN P.-BITICCHI R.-PALOMBI F.-PUGLISI R.-BOITANI C.-CANCEDDA R.-CASTAGNOLA P.
Impaired expression of genes coding for reactive oxygen species scavenging enzymes in testes of Mtfr1/Chppr deficient mice.
Reproduction 134:483/492, 2007
PubMed Abstract
NARCISO L.-FORTINI P.-PAJALUNGA D.-FRANCHITTO A.-LIU P.-DEGAN P.-FRECHET M.-DEMPLE B.-CRESCENZI M.-DOGLIOTTI E.
Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury.
Proc. Natl. Acad. Sci. USA 104:17010/17015, 2007
PubMed Abstract
ROPOLO M.-DEGAN P.-FORESTA M.-D'ERRICO M.-LASIGLIE' D.-DOGLIOTTI E.-CASARTELLI G.-ZUPO S.-POGGI A.-FROSINA G.
Complementation of the oxidatively damaged DNA repair defect in Cockayne syndrome A and B cells by Escherichia coli
formamidopyrimidine DNA glycosylase.
Free Radic. Biol. Med. 42:1807/1817, 2007
PubMed Abstract
ZATTERALE A.-KELLY F.-DEGAN P.-D'ISCHIA M.-PALLARDO' F.-CALZONE R.-DUNSTER C.-LLORET A.-MANINI P.-COGULU O.-KAVAKLI K.-PAGANO G.
Oxidative stress biomarkers in four Bloom syndrome (BS) patient and in their parents suggest in vivo redox abnormalities in BS phenotype.
Clin. Biochem. 40:1100/1103, 2007
PubMed Abstract
BESTOSO F.-OTTAGGIO L.-ARMIROTTI A.-BALBI A.-DAMONTE G.-DEGAN P.-MAZZEI M.-CAVALLI F.-LEDDA B.-MIELE M.
In vitro cell cultures obtained from different explants of Corylus avellana produce Taxol and taxanes.
BMC Biotechnol. 6:45;1/45;11, 2006
PubMed Abstract
BLASI M.-VENTURA I.-AQUILINA G.-DEGAN P.-BERTARIO L.-BASSI C.-RADICE P.-BIGNAMI M.
A human cell based assay to evaluate the effects of alterations in the MLH1 mismatch repair gene.
Cancer Res. 66:9036/9044, 2006
PubMed Abstract
D'ERRICO M.-PARLANTI E.-TESON M.-DE JESUS B.-DEGAN P.-CALCAGNILE A.-JARUGA P.-BJORAS M.-CRESCENZI M.-PEDRINI A.-EGLY J.-ZAMBRUNO G.-
STEFANINI M.-DIZDAROGLU M.-DOGLIOTTI E.
New functions of XPC in the protection of human skin cells from oxidative damage.
EMBO J. 25:4305/4315, 2006
PubMed Abstract
FROSINA G.
Prophylaxis of oxidative DNA damage by formamidopyrimidine DNA glycosylase.
Int. J. Cancer 119:1/7, 2006
PubMed Abstract
MAGRINI R.-RUSSO D.-FRONZA G.-INGA A.-MENICHINI P.
The kinetics of p53 binding and histone acetylation at target promoters do
not strictly correlate with gene expression after UV damage.
J. Cell. Biochem. 100:1276/1287, 2007 - Epub Oct 24, 2006
PubMed Abstract
OTTAGGIO L.-CAMPOMENOSI P.-FRONZA G.-MENICHINI P.-MIELE M.-MORO F.-VIAGGI S.-ZUNINO A.-ABBONDANDOLO A.
Stable formation of mutated p53 multimers in a chinese hamster cell line causes defective p53 nuclear localization and abrogates its residual function.
J. Cell. Biochem. 98:1689/1700, 2006
PubMed Abstract
PALLARDO' F.-DEGAN P.-D'ISCHIA M.-KELLY F.-ZATTERALE A.-CALZONE R.-CASTELLO G.-FERNANDEZ R.-DUNSTER C.-LLORET A.-MANINI P.-PISANTI M.-VUTTARIELLO E.-PAGANO G.
Multiple evidence for an early age pro oxidant state in Down syndrome patients.
Biogerontology 7:211/220, 2006
PubMed Abstract
PERFUMO C.-BONELLI L.-MENICHINI P.-INGA A.-GISMONDI V.-CIFERRI E.-PERCIVALE P.L.-BIANCHI G.-NASTI S.-FRONZA G.-VARESCO L.
Increased risk of colorectal adenomas in italian subjects carrying the p53 PIN3 A2/Pro72 haplotype.
Digestion 74:228/235, 2006
PubMed Abstract
ROPOLO M.-GEROLDI A.-DEGAN P.-ANDREOTTI V.-ZUPO S.-POGGI A.-REED A.-KELLEY M.-FROSINA G.
Accelerated repair and reduced mutagenicity of oxidative DNA damage in human bladder cells expressing the E. coli FPG protein.
Int. J. Cancer 118:1628/1634, 2006
PubMed Abstract
RUSSO M.-DE LUCA G.-DEGAN P.-BIGNAMI M.
Different DNA repair strategies to combat the threat from 8/oxoguanine.
Mutat. Res. Fund. Mol. M. 614:69/76, 2007 - Epub Jun 10, 2006
PubMed Abstract
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